Overview

Nandrolone decanoate is an androgen and anabolic steroid (AAS) medication which is used in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women.  
It is given by injection into muscle  once every one to four weeks.
The medication is a synthetic androgen and anabolic steroid and is an agonist of the androgen receptor (AR).It has strong anabolic effects and weak androgenic effects, which give it a mild side effect and make it especially suitable for use in women and children. Nandrolone decanoate is a nandrolone ester and a long-lasting prodrug of nandrolone inside the body.
It is one of the most widely used nandrolone esters. In addition to its medical use, nandrolone decanoate is used to improve physique and performance. The drug is a controlled substance in many countries and so non-medical use is generally illicit.

Therapeutic Indication

• For the treatment of refractory deficient red cell production anemias, breast carcinoma
• hereditary angioedema, antithrombin III deficiency
• fibrinogen excess, growth failure and Turner's syndrome.
• It is also indicated in the prophylaxis of hereditary angioedema.
• androgen replacement therapy for treatment of androgen deficiency in men

Pharmacology

Mechanism of action

Nandrolone may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor,it has less overall effect on muscle growth.  It is an androgen receptor agonist. The drug bound to the receptor complexes which allows it to enter the nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

Pharmacodynamics

Nandrolone is an anabolic steroid occurring naturally in the human body. Nandrolone increases production and urinary excretion of erythropoietin. It may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone.Nandrolone decanoate is a nandrolone ester, or a prodrug of nandrolone. As such, it is an androgen and anabolic steroid, or an agonist of the AR, the biological target of androgens like testosterone and DHT. Relative to testosterone, nandrolone decanoate has enhanced anabolic effects. It is considered to have strong anabolic effects but weak androgenic effects. Along with oxandrolone (which has a ratio of about 10:1), nandrolone esters are thought to have the highest ratio of anabolic to androgenic effect of any other AAS. Due to this reason, they are considered to be among the most appropriate AAS for use in women and children. The low androgenicity of nandrolone decanoate is thought to be due to the fact that whereas many other AAS like testosterone are potentiated via transformation by 5α-reductase into more potent AR agonists like DHT in specific tissues including the skin, hair follicles, prostate gland, liver, and brain, nandrolone is instead inactivated by 5α-reductase via transformation into the low-affinity AR ligand  such tissues. In addition to its anabolic and androgenic activity, nandrolone decanoate has low estrogenic activity and moderate progestogenic activity.This may result in side effects such as fluid retention and gynecomastia

Pharmacokinetics

Nandrolone decanoate is stored unchanged and is slowly absorbed into the body.Once in the circulation, it is converted into nandrolone, A active form of the drug.There is a sharp spike in nandrolone levels 24 to 48 hours after an intramuscular injection of nandrolone decanoate, followed by a steady decline to baseline levels within two or three weeks. The bioavailability of nandrolone decanoate is 53 to 73% with intramuscular injection and varies with the site of injection. It has very low affinity for sex hormone-binding globulin . Nandrolone decanoate is rapidly hydrolyzed in the blood by esterases into nandrolone, It does not appear to be hydrolyzed in muscle or fat. The metabolism of nandrolone occurs in the liver and is very similar to that of testosterone, including reduction by 5α-reductase and 5β-reductase, dehydrogenation by 3α-hydroxysteroid dehydrogenase,  and conjugation.The metabolites of nandrolone include 5α-dihydronandrolone, 19-norandrosterone, with 19-norandrosterone being the major metabolite. The elimination half-life of nandrolone decanoate administered by intramuscular injection is approximately 6 to 12 days. The duration of nandrolone decanoate via its anabolic effects, for instance on nitrogen balance, have found that a single 50 to 100 mg intramuscular injection had a duration of about 18 to 25 days. Nandrolone and its metabolites are excreted in the urine, mainly in the form of conjugates. The pharmacokinetics of nandrolone decanoate via subcutaneous injection closely resemble those of intramuscular injection.Subcutaneous injection is considered to be easier, more convenient, and less painful compared to intramuscular injection.In addition, research suggests that most intramuscular injections in practice are in fact subcutaneous injections.

Contraindications

Contraindications for nandrolone decanoate include pregnancy, breastfeeding, prostate cancer, male breast cancer, breast cancer in women with hypercalcemia, hypersensitivity excipients such as arachis (peanut) oil; includes those with peanut and soy allergies . High dosages may also be considered contraindicated in women due to their high potential for virilization.

Pregnancy and Lactation:Contact your doctor before using this.

Side Effects

symptoms of masculinization, acne, increased hair growth, voice changes, increased sexual desire, fluid retention, inhibition of spermatogenesis, testicular atrophy, erectile dysfunction, gynecomastia, increased frequency of penile erections,hypertension, nausea, epididymitis, bladder irritability